To save your publication
1. On the File menu, click Save.
2. In the File Name box, type a name for your calendar.
3. If necessary, move to the drive and folder in which you want to save your calendar.
Click the Save button to save the file.
When you open a file that you have saved and want to make changes, but save the original that you opened, use 'SAVE AS', to save it as a different file.
look for more answers on the Microsoft website for the Publisher 2000 Tutorial
http://www.microsoft.com/Education/Publisher2000Tutorial.aspx
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